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Deprescribing Inappropriate Proton Pump Inhibitors

NCT06129474 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2026-05-14

No results posted yet for this study

Summary

The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting. It aims to evaluate an intervention to guide the deprescribing of inappropriate proton-pump inhibitors (PPIs). Therefore, the trial investigates whether the study intervention leads to the deprescribing of inappropriate PPI prescription while ensuring noninferiority safety, in comparison to usual care. Additionally, the trail aims to investigate the intervention's impact on other clinical aspects, as well as addressing features of the implementation of the intervention and its cost-effectiveness.

Conditions

  • Inappropriate Prescribing
  • Reflux Disease
  • Proton Pump Inhibitors

Interventions

OTHER

Proton Pump Inhibitor deprescribing tool

The intervention is targeted to the Swiss Primary care practice. It involves educational material and resources to guide the safe deprescribing of inappropriate PPIs, for both general practitioners and patients.

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • University of Zurich

    collaborator OTHER

  • University of Basel

    collaborator OTHER

  • Insel Gruppe AG, University Hospital Bern

    collaborator OTHER

  • Patientenstelle Zürich

    collaborator UNKNOWN

  • Patientenstelle Basel

    collaborator UNKNOWN

  • Centre Hospitalier Universitaire Vaudois

    collaborator OTHER

  • University of Bern

    lead OTHER

Principal Investigators

  • Sven Streit, Prof. Dr. med. Dr. phil · University of Bern, Institute of Primary Health Care (BIHAM)

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-01
Primary Completion
2027-04-30
Completion
2027-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06129474 on ClinicalTrials.gov