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Placebo-Controlled Crossover Study for the Investigation of the Effect of Pantoprazole on Cardiac Contractility

NCT00600041 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2009-03-24

No results posted yet for this study

Summary

Recently, negative inotropy of pantoprazole has been shown in isolated human myocardium. This study was designed to test the clinical relevance of this finding in healthy volunteers by measuring left ventricular function during infusion of a common intravenous high dose regimen of pantoprazole.

Conditions

  • Healthy

Interventions

DRUG

Pantoprazole

80 mg IV over 2 minutes, followed by 8 mg/h IV for 60 minutes

DRUG

Placebo

Identical infusion manner like experimental arm

Sponsors & Collaborators

  • University of Göttingen

    collaborator OTHER

  • Gastroenterology and Endocrinology, University Medicine of Goettingen

    collaborator OTHER

  • Medical Statistics, University Medicine of Goettingen

    collaborator OTHER

  • Herzzentrum Goettingen

    lead OTHER

Principal Investigators

  • Gerd Hasenfuss, Prof. Dr. · Herzzentrum Goettingen

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-05-31
Primary Completion
2006-01-31
Completion
2006-11-30

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00600041 on ClinicalTrials.gov