MedTrace Logo

Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)

NCT06129253 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 29750

Last updated 2025-07-16

No results posted yet for this study

Summary

This study is a multi-country and multi-site project to estimate the point-prevalence of high-risk (HR) HPV genotype infections among representative samples of girls and women aged 9-50 years, and among specific sub-populations to estimate the incidence of persistent HPV infection among sexually active young women. The data to fulfill the objectives will be collected through a series of Cross-Sectional Surveys (CSS) and Longitudinal Studies (LS) in all 8 countries 3 South Asian countries including Bangladesh, Pakistan, Nepal and 5 sub-Saharan African countries including Sierra Leone, Tanzania, Ghana, Zambia and DR Congo. Qualitative sub-studies (QS) will be conducted in selected countries and populations following the CSS to further understand and unpack risk factors for HPV infection as well as to explore how gender-related dynamics including perceptions of gender norms and stigma, influence HPV burden and/or create barriers that shape girls/women access to and uptake of HPV prevention, screening, and treatment services. Specific study protocols and corresponding ethical applications for the qualitative sub-studies will be developed separately.

Conditions

Interventions

OTHER

Urine Sample Collection

When urine is collected as a sample in either CSS or LS, first flow urine samples will be collected

OTHER

Self-collected Vaginal Swab

Self-collected Vaginal Swab will be collected by the participant under the supervision of a trained nurse or other health care worker.

OTHER

Blood Samples

If funding permits, a blood sample may be collected from participants in LS once during the follow-up period. If blood sample collection was not feasible during a visit, two additional attempts may be made to collect blood samples from LS participants during the subsequent follow-up visits.

Sponsors & Collaborators

Principal Investigators

  • Alexandra Hill · Associate Research Scientist

  • Deborah Watson-Jones · Professor of Clinical Epidemiology & International Health

Eligibility

Min Age
9 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-23
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • Bangladesh
  • Democratic Republic of the Congo
  • Ghana
  • Nepal
  • Pakistan
  • Sierra Leone
  • Tanzania
  • Zambia

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06129253 on ClinicalTrials.gov