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A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles

NCT06115655 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 161

Last updated 2023-11-03

No results posted yet for this study

Summary

The goal of this observational study is to detect the methylation characteristics of cfDNA in the bile and plasma of patients with bile duct stricture. The main question it aims to answer is: Can the developed model, using peripheral blood and bile cell-free DNA sequencing, work well in screening and classifying unknown biliary stricture? Participants will collect approximately 10ml of peripheral blood and 5ml of bile from the patient.

Conditions

  • Bile Duct Neoplasms
  • Jaundice, Obstructive
  • Bile Duct Diseases

Interventions

DIAGNOSTIC_TEST

cfDNA methylation detection

Extract cfDNA from bile and plasma, and perform methylation detection.

Sponsors & Collaborators

  • Air Force Military Medical University, China

    lead OTHER

Principal Investigators

  • Yanglin Pan, MD · The First Affiliated Hospital of the Air Force Medical University

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2024-10-01
Completion
2024-10-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06115655 on ClinicalTrials.gov