Early vs Postponed Parenteral Nutrition After Emergency Abdominal Surgery

Summary

The aim of this study is to investigate the effect of early, supplementary parenteral nutrition following emergency laparotomy.

Currently, parenteral nutrition is used in postoperative patients if or when oral or enteral nutrition is not feasible. However, little data exists on the optimal timing of parenteral nutrition.

Oral and enteral nutrition is encouraged. Participants will randomized on the second postoperative day if their calorie intake (oral + enteral) is below 50% of the calculated requirement. Patients will be randomized to early (postoperative day 2) or postponed (postoperative day 5) start of parenteral nutrition.

The combined oral + enteral + parenteral calorie target is 70-80% of the calculated requirement. Participants in the postponed group will be re-assessed on postoperative day 5, and if their calorie intake is less than 50% parenteral nutrition will be administered.

The intervention will continue until oral + enteral intake is at least 70% of the calculated requirement or the participant is at his/her habitual intake.

Conditions

• Laparotomy
• Bowel Obstruction
• Ischemia, Mesenteric

Interventions

DRUG

SmofKabiven

Participants will receive supplementary parenteral nutrition based on their calorie intake. The dosage will be adjusted on a daily basis depending on intake.

Sponsors & Collaborators

• Copenhagen University Hospital, Hvidovre

  collaborator OTHER

• Nordsjaellands Hospital

  collaborator OTHER

• Slagelse Sygehus

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Gødstrup Hospital

  collaborator OTHER

• Aalborg University Hospital

  collaborator OTHER

• Bispebjerg Hospital

  collaborator OTHER

• Zealand University Hospital

  collaborator OTHER

• Holbaek Sygehus

  collaborator OTHER

• Copenhagen University Hospital at Herlev

  lead OTHER

Principal Investigators

• Jannick B Hansen, M.D. · Copenhagen University Hospital at Herlev

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-10-18

Primary Completion

2025-10-25

Completion

2026-01-01

Countries

• Denmark

Study Locations