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Perioperative Methadone Compared to Placebo in Elderly Hip Fracture Patients

NCT06086171 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 129

Last updated 2025-03-18

No results posted yet for this study

Summary

Hip fractures are associated with severe pain and are sustained by the elderly population. Demand for adequate pain relief combined with a low tolerance for analgesic drugs makes the treatment of elderly hip fracture patients difficult. Perioperative methadone could improve the analgesic treatment of these patients. An earlier pilot study showed that 0.10 mg/kg was safe to use. This study further investigates the advantages of methadone. The study's objective is to investigate the analgesic effects of a single dose of methadone given during hip fracture surgery.

Conditions

  • Hip Fractures
  • Methadone

Interventions

DRUG

Methadone Hydrochloride

Methadone hydrochloride (0.10 mg/kg) administered intravenously at the induction of anaesthesia

OTHER

Placebo

Saline solution

Sponsors & Collaborators

  • University of Southern Denmark

    lead OTHER

Principal Investigators

  • Jesper Ougaard Schønnemann · Sygehus Sønderjylland (Region Syddanmark)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-10
Primary Completion
2024-10-29
Completion
2025-02-21

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06086171 on ClinicalTrials.gov