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The Effects of Antibiotic Exposure in Early Infancy on Vaccine Responses

NCT06079606 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-12-18

No results posted yet for this study

Summary

This prospective cohort study will include 200 term children born in Landspitali University Hospital in Iceland. The cohort will be divided into four groups according to antibiotic exposure of which one is the control group. Children's immune responses to live oral rotavirus vaccine as well as conventional vaccinations given at three, five and 12 months old will be determined by measuring salivary and serologic responses. Responses will be compared between the four groups. Stool samples will also be collected from participants and the composition of the microbiome compared between the four groups.

Conditions

  • Immune Responses
  • Antibiotic Treatment

Interventions

OTHER

Antibiotic treatment

Children will be assigned to groups according to antibiotic exposure in early life. No antibiotics will be given in the study.

Sponsors & Collaborators

  • Landspitali University Hospital

    lead OTHER

Eligibility

Max Age
6 Weeks
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-10
Primary Completion
2025-02-28
Completion
2027-12-31

Countries

  • Iceland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06079606 on ClinicalTrials.gov