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Traumatic Events in Childhood, Attachment, Pain Perception, Epigenetic Marks, Quality of Life and Resilience.

NCT06077097 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-07-25

No results posted yet for this study

Summary

In the present research study, aiming to explore the links between several psychological factors and chronic pain, the research seeks to develop an inclusive framework to investigate the role of adverse childhood experiences (ACEs) in patients' pain perception and overall quality of life throughout their pain management programs. Specifically, attachment styles (AS) and pain-related resilience processes are considered as potential mediators of the effectiveness of chronic pain management programs. Additionally, biological measures are proposed to investigate physiological parameters of pain and to further explore the degree of consistency between self-reported measures, ACEs, ASs, chronic stress, and several epigenetic biomarkers.

Conditions

  • Chronic Pain
  • Adverse Childhood Experiences
  • Attachment Styles
  • Chronic Stress
  • Resilience, Psychological
  • Quality of Life
  • Epigenesis, Genetic

Interventions

GENETIC

Biological samples

This project also includes an auxiliary exploratory biological study of subcellular mechanisms, using high-throughput sequencing (Next Generation Sequencing, NGS) to identify gene expression variations in order to determine the resilience/vulnerability of the variables studied with respect to the DC experience (cytogenetics and transcriptome).

Sponsors & Collaborators

  • University of Lorraine

    lead OTHER

Principal Investigators

  • CYRIL CYRIL, Pr · UR 4360 APEMAC, UNIVERSITY OF LORRAINE

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-12
Primary Completion
2024-12-18
Completion
2024-12-18

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06077097 on ClinicalTrials.gov