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Respiratory and Hemodynamic Targets During General Anesthesia

NCT06047119 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 485

Last updated 2025-08-05

No results posted yet for this study

Summary

This trial is an investigator-initiated, multicenter, randomized, factorial, single-blind trial of multiple hemodynamic and respiratory targets during general anesthesia. These targets include blood pressure, positive end expiratory pressure, tidal volume, and fraction of inspired oxygen. Patients will be randomized to different targets using a factorial design, i.e., each patient is simultaneously randomized to four interventions. There will be five enrolling sites in the Central Denmark Region. 480 high-risk patients will be enrolled.

Conditions

  • Patients Undergoing General Anesthesia

Interventions

PROCEDURE

Blood pressure

Blood pressure targets during general anesthesia and 2 hours after

PROCEDURE

Positive end expiratory pressure

Positive end expiratory pressure during general anesthesia

PROCEDURE

Tidal volume

Tidal volume during general anesthesia

PROCEDURE

Fraction of inspired oxygen

Fraction of inspired oxygen during general anesthesia and 2 hours after

Sponsors & Collaborators

  • Lars Wiuff Andersen

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-09
Primary Completion
2025-04-24
Completion
2025-04-24

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06047119 on ClinicalTrials.gov