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Migraine With Aura and Patent Foramen Ovale: Identification of Biomarkers to Select Patients In Whom Intervention Would Be Beneficial (MANET)

NCT06046508 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2024-02-08

No results posted yet for this study

Summary

This is a multicenter prospective observational study aimed to asses whether a specific prothrombotic platelet phenotype can discern migraine patients with PFO (patent forame ovale) - related symptoms from patients with incidental PFO. The study will also explore additional distinguishing features of causal and incidental PFO using a metabolomics approach. It involves the enrollment of well-characterized patient cohorts and an ex vivo approach using comparative cell biology models that reproduce the most critical aspects of the clinical scenario.

Conditions

  • Migraine Headache
  • PFO - Patent Foramen Ovale

Interventions

OTHER

blood samples collection

patients, who meet all the inclusion criteria and none of the exclusion criteria, will be enrolled and they will perform a blood withdrawal before PFO correction and 180 days after the intervention

Sponsors & Collaborators

  • IRCCS Policlinico S. Donato

    collaborator OTHER

  • Università di Cagliari

    collaborator UNKNOWN

  • Federico II University

    collaborator OTHER

  • Centro Cardiologico Monzino

    lead OTHER

Principal Investigators

  • Daniela Trabattoni, MD · IRCCS Centro Cardiologico Monzino

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-18
Primary Completion
2025-04-30
Completion
2025-04-30

Countries

  • Italy

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06046508 on ClinicalTrials.gov