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Effect of Azole/Echinocandin Use on Tacrolimus Pharmacokinetics

NCT06044558 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 507

Last updated 2023-09-28

No results posted yet for this study

Summary

The purpose of this observational study is to analyze the extent and characteristics of drug interactions (focusing on azole antifungals and echinocandins) and genetic polymorphisms on tacrolimus blood concentrations in renal transplant recipients in order to provide a reference for the appropriate adjustment of tacrolimus dosing regimen to reduce the incidence of adverse drug reactions and rejection, and to improve the survival of transplanted kidneys.

Conditions

  • Kidney Transplant Patients

Interventions

DRUG

Combined with voriconazole

Renal transplant patients taking tacrolimus-based triple immunotherapy and voriconazole drug combination.

DRUG

Combined with caspofungin

Renal transplant patients taking a combination of tacrolimus-based triple immunotherapy and caspofungin drugs.

DRUG

Tacrolimus-alone treatment

Renal transplant patients treated with tacrolimus-based triple immunotherapy alone

Sponsors & Collaborators

  • LI YAN

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-01
Primary Completion
2023-01-01
Completion
2023-06-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06044558 on ClinicalTrials.gov