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Long-Term Pharmacokinetics of Tacrolimus in Renal Recipients

NCT00411944 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2006-12-15

No results posted yet for this study

Summary

An evaluation of the effects of genetically determined variant metabolizing and transporting proteins involved in the disposition of the immunosuppressive drug tacrolimus in renal transplant recipients. In a five year follow-up study tacrolimus dose-corrected exposure changes significantly and the effect(s) of single nucleotide polymorphisms of the CYP3A4/CYP3A5 and MDR1 genes on the latter is assessed in this study.

Conditions

  • Renal Transplantation

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Dirk R Kuypers, MD, PhD · Dpt Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-08-31
Completion
2005-09-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00411944 on ClinicalTrials.gov