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Estrogen and Microvascular Function

NCT06043310 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2025-07-04

No results posted yet for this study

Summary

The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults.

Participants will:

* give one blood draw of 5 mL
* have one Dexa Scan taken to measure adipose and muscle mass
* have a camera placed under the tongue to take pictures of blood vessels
* have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion

Researchers will compare blood vessel function of those who take estrogen to those who do not.

Conditions

Interventions

DRUG

Nω-nitro-L-arginine methyl ester (L-NAME)

L-NAME will be infused locally through microdialysis catheters.

DRUG

Acetylcholine

ACh will be infused locally through microdialysis catheters.

DRUG

Sodium Nitroprusside

SNP will be infused locally through microdialysis catheters.

Sponsors & Collaborators

  • Medical College of Wisconsin

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-12
Primary Completion
2031-12-31
Completion
2031-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06043310 on ClinicalTrials.gov