Study on the Dynamic Changes of Metabolic Biomarkers and Their Prognostic Relationship in Ovarian Cancer
NCT06019923 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100
Last updated 2025-07-17
Summary
Ovarian cancer is a highly lethal gynecological malignancy, often diagnosed at an advanced stage, with high rates of recurrence within 1-2 years after frontline treatment. Current guidelines recommend monitoring tumor markers CA125 and HE4 for disease progression, but these markers may not detect recurrence or disease progression when their levels are below the detection limit. Therefore, there is a need to identify new prognostic biomarkers and monitor their dynamic changes for effective risk stratification and personalized treatment in patients with ovarian cancer
Conditions
Interventions
- OTHER
-
No intervention
No intervention
Sponsors & Collaborators
-
Women's Hospital School Of Medicine Zhejiang University
lead OTHER
Principal Investigators
-
Hongyu Xie, phD · Women's Hospital School Of Medicine Zhejiang University
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-10-26
- Primary Completion
- 2026-09-10
- Completion
- 2027-09-10
Countries
- China
Study Locations
More Related Trials
-
Bespoke ctDNA Assay for Recurrence and Treatment Response Monitoring in Advanced Epithelial Ovarian Cancer
NCT05446545 ·Status: RECRUITING
-
Tumor Microenvironment in Ovarian Cancer
NCT06272240 ·Status: RECRUITING
-
Evaluation of Prognostic Monitoring for Women Who Have Completed Standard Treatment for Ovarian Cancer
NCT05410015 ·Status: RECRUITING
-
A Biomarker Exploration Study of Precision Treatment in Ovarian Cancer
NCT06483425 ·Status: ACTIVE_NOT_RECRUITING
-
Cytoreductive Surgery in Platinum-resistant Recurrent Ovarian Cancer
NCT05633199 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
The Culture of Advanced or Recurrent Ovarian Cancer Organoids and Drug Screening
NCT05290961 ·Status: UNKNOWN
-
To Explore the Feasibility of Dynamic Changes of TCR Diversity in Peripheral Blood in Monitoring Recurrence and Evaluating Prognosis of Epithelial Ovarian Cancer
NCT06315270 ·Status: NOT_YET_RECRUITING
-
Individualized Health Management of Epithelial Ovarian Cancer: A Retrospective Study
NCT06085456 ·Status: RECRUITING
-
Circulating Tumor DNA Monitoring in Platinum-resistant Ovarian Cancer
NCT05976932 ·Status: UNKNOWN
-
Hyperthermic Intraperitoneal Chemotherapy for Recurrent Ovarian Cancer
NCT02672098 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom
NCT00757263 ·Status: UNKNOWN
-
Genomic Profiling of the Residual Disease of Advanced-stage Ovarian Cancer After Neoadjuvant Chemotherapy
NCT03491033 ·Status: COMPLETED
-
The Efficacy of Hyperthermic Intraperitoneal Chemotherapy to Ovarian Cancer Patients With Homologous Recombination Repair Defect and Residual: a Prospective Cohort Study
NCT05265117 ·Status: UNKNOWN
-
Metabolite Levels in Ovarian Cancer Patients Receiving Maintenance PARP Inhibitors
NCT04917744 ·Status: COMPLETED
-
A Cohort Establishment Study of Total Management of Ovarian Cancer
NCT06018935 ·Status: RECRUITING
-
Genetic Mutation in Epithelial Ovarian Cancer
NCT04191252 ·Status: UNKNOWN
-
Risk of Ovarian Cancer in Patients With a Pelvic Mass
NCT00315692 ·Status: COMPLETED
-
Ovarian Malignancy Incidence in Moderate Risk Women With Low CA 125
NCT02247323 ·Status: UNKNOWN
-
HE4 as a Relapse Biomarker in Ovarian Cancers
NCT02595281 ·Status: COMPLETED ·Phase: NA
-
Diagnosis of Epithelial Ovarian Cancer Using Ovarian Cancer Score (OCS) Test
NCT06366997 ·Status: COMPLETED
-
Study of the Impact on Survival of a Paradigm Shift in the Therapeutic Strategy of Patients With Advanced Ovarian Cancer
NCT06907771 ·Status: RECRUITING
-
Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary
NCT00626873 ·Status: COMPLETED ·Phase: PHASE1
-
The Culture of Ovarian Cancer Organoids and Drug Screening
NCT04768270 ·Status: UNKNOWN
-
Hyperthermic Intraoperative Intraperitoneal Chemotherapy of Recurrent Ovarian Cancer - A Feasibility Study
NCT00968799 ·Status: TERMINATED ·Phase: NA
-
Biomarkers in Predicting Response in Patients With Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Treated on GOG-0172 or GOG-0182
NCT01074398 ·Status: UNKNOWN