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MRI-based Synthetic CT Images of the Head and Neck

NCT06016335 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2023-12-19

No results posted yet for this study

Summary

In case of surgical procedures in the head and neck region, MRI in combination with CT of the bone is often the standard modality to visualise bony landmarks for planning, navigation and risk assessment. An important downside of a CT scan is the associated radiation exposure, especially in children. An additional downside is the sedation or general anaesthesia needed for both the MRI and CT scan session in very young children. These downsides could be removed if the CT scan can be substituted by an MRI sequence that can provide the same information as CT. This project aims to determine the feasibility of recreating CT like images of the craniofacial bones from MRI images using machine learning techniques.

Conditions

  • Imaging of Bony Structures of the Head (Various Conditions)
  • Hearing Loss
  • Cholesteatoma
  • Sinusitis
  • Head and Neck Tumor

Interventions

DIAGNOSTIC_TEST

CT scan

Participants receive a CT scan of the head as part of their regular care. A larger part of the head will be scanned than for standard care.

DIAGNOSTIC_TEST

MRI scan

Participants receive an MRI scan, specifically for the purpose of the study.

OTHER

Synthetic CT scan

Synthetic CT scans will be generated from MRI scans, using the trained machine learning algorithm.

Sponsors & Collaborators

  • MRIguidance B.V.

    collaborator INDUSTRY

  • Amsterdam UMC, location VUmc

    lead OTHER

Principal Investigators

  • Paul Merkus, MD PhD · Amsterdam UMC, location VUmc

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-22
Primary Completion
2023-09-12
Completion
2023-09-12

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06016335 on ClinicalTrials.gov