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Multi-parametric Imaging in Personalized Radiotherapy

NCT05888064 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2024-08-21

No results posted yet for this study

Summary

The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.

Conditions

  • Skull Base Chordoma

Interventions

DIAGNOSTIC_TEST

diffusion MRI sequences

Diffusion MRI sequences will be optimized to derive more accurate estimates of microstructure and microvasculature of tumour and healthy organs: multiple b-values will be acquired and advanced diffusivity models considered. MRI sequences to derive tumour hypoxia (i.e. indicative of radioresistance) will be also considered along with MR spectroscopy to evaluate tumour microenvironment.

Sponsors & Collaborators

  • Dept. of Electronics, Informatics, Bioengineering, Politecnico di Milano, Italy

    collaborator OTHER

  • CNAO National Center of Oncological Hadrontherapy

    lead OTHER

Principal Investigators

  • Alberto Iannalfi, MD · CNAO National Center of Oncological Hadrontherapy

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-19
Primary Completion
2025-08-18
Completion
2025-08-18

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05888064 on ClinicalTrials.gov