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Cerebral Changes Following CTS Treated With Guided Plasticity

NCT06016049 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2023-08-29

No results posted yet for this study

Summary

70 patients with mild to moderate Carpal tunnel Syndrome (CTS) including 24 patients with unilateral CTS were randomized to treatment with ipsilateral cutaneous forearm deafferentation with an anesthetic cream (EMLA®) or placebo during 8 weeks. Patient-rated outcomes was assessed using the symptom severity scale from the Boston carpal tunnel syndrome questionnaire (BCTQ) and the disability of arm, shoulder and hand questionnaire(Quick-DASH). Clinically patients were assessed for tactile discrimination and dexterity and nerve conduction studies (NCS). Cortical activation during sensory stimulation was evaluated with functional magnetic resonance imaging (fMRI) at 3T. Assessments were performed at baseline, after 90 min of initial treatment, and after 8 weeks.

Conditions

  • Carpal Tunnel Syndrome

Interventions

OTHER

EMLA® adjuvant

cutaneous forearm deafferentation

BEHAVIORAL

Sensory training

Sensibility training of the median nerve

Sponsors & Collaborators

  • Region Skane

    lead OTHER

Principal Investigators

  • Magnus Flondell, MD PhD · Institute of Translational Sciences Malmö, Lund University

  • Anders Björkman, MD, Prof. · Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-01
Primary Completion
2015-11-01
Completion
2015-11-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06016049 on ClinicalTrials.gov