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CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.

NCT06005363 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2023-08-22

No results posted yet for this study

Summary

In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.

Conditions

  • The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation
  • The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change

Interventions

DRUG

Dexmedetomidine

dexmedetomidine infusion

DEVICE

anesthesia depth monitoring

intraoperative anesthesia depth monitoring to keep BIS 40-60

Sponsors & Collaborators

  • Chang Gung Memorial Hospital

    lead OTHER

Principal Investigators

  • Huan-tang Lin · Department of anesthesiology, Linkou Chang Gung Memorial Hospital

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06005363 on ClinicalTrials.gov