Optimizing Early Nutrition Support in Severe Stroke-2

Summary

Post stroke pneumonia (PSP) is one of the common early complications of stroke. Post-stroke infections, in general, are associated with less favorable neurologic outcomes. Aspiration is one of the most feared complications of enteral nutrition and can lead to the occurrence of pneumonia. Severe stroke patients are at high risk for aspiration due to some factors such as the reduced level of consciousness, inability to protect the airway and so on. The purpose of this study is to explore the ideal nutrition support strategy for patient with acute severe stroke to help reduce the incidence of PSP and improve the prognosis.

Conditions

• Severe Stroke
• Acute Stroke
• Dysphagia

Interventions

PROCEDURE

Trophic enteral feeding combined with supplemental parenteral nutrition

The caloric goal of the first day is one-third of caloric requirements, the second day is half of caloric requirements, the third day is 70-100% and sustained for 1 week. Patients will receive the trophic enteral feeding with a caloric target of 500kcal/d (20-35ml/h), and the remaining calories are supplemented by parenteral nutrition. Protein requirements are calculated at 1.2 to 1.5 g per kilogram of body weight per day.

PROCEDURE

Full enteral feeding

The caloric goal of the first day is one-third of caloric requirements, the second day is half of caloric requirements, the third day is 70-100% and sustained for 1 week. Protein requirements are calculated at 1.2 to 1.5 g per kilogram of body weight per day. Enteral nutrition is given through nasogastric tube or nasointestinal tube.

Sponsors & Collaborators

• Tang-Du Hospital

  collaborator OTHER

• Xi'an Central Hospital

  collaborator OTHER

• Xi'an Gaoxin Hospital

  collaborator OTHER

• First Affiliated Hospital Xi'an Jiaotong University

  collaborator OTHER

• Xi'an No.3 Hospital

  collaborator OTHER_GOV

• First People's Hospital of Xianyang

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• The Second Hospital of Shandong University

  collaborator OTHER

• PLA 960 Hospital

  collaborator UNKNOWN

• Daping Hospital, The Third Military Medical University (Army Medical University)

  collaborator UNKNOWN

• The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

  collaborator UNKNOWN

• First Hospital Affiliated to Zhengzhou University

  collaborator UNKNOWN

• Gansu Provincial Central Hospital

  collaborator UNKNOWN

• The First Hospital of Changsha City

  collaborator UNKNOWN

• Shaanxi Provincial People's Hospital

  collaborator OTHER

• Yulin No.2 Hospital

  collaborator OTHER

• Yulin No.1 Hospital

  collaborator UNKNOWN

• Xijing Hospital

  collaborator OTHER

• Wen Jiang-3

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-12-20

Primary Completion

2026-07-31

Completion

2026-10-31

Countries

• China

Study Locations