Cohort Study for Severe Ischaemic Stroke

Summary

This is a multi-centre, prospective cohort study. The aim of this study is to investigate causes, risk factors, clinical course, management and outcomes of severe ischaemic stroke in a real-world setting in tertiary hospitals in China. Patients with acute ischaemic stroke from nine tertiary hospitals in western China will be recruited. Participants will be visited within 24 hours after admission, on day 3, day 7 and at discharge, to collect their clinical data, blood biomarkers, and brain imaging. A structured telephone interview will be conducted for each participant at 3 months and 1 year after stroke onset, respectively, to collect their functional outcomes. In-hospital outcomes include haemorrhagic transformation, brain oedema and death, 3-month and 1-year outcomes include survival status (death or survival) and functional outcome (scores of modified Rankin scale, mRS).

Conditions

• Severe Ischaemic Stroke
• Malignant Ischaemic Stroke

Interventions

OTHER

routine medical care

This is an observational study for clinical course and outcomes of severe ischaemic stroke; therefore, interventions are prescribed by responsible doctors based on patients' clinical conditions, which is not interfered by current study

Sponsors & Collaborators

• Sichuan Academy of Medical Sciences

  collaborator OTHER

• The Affiliated Hospital Of Southwest Medical University

  collaborator OTHER

• Affiliated Hospital of North Sichuan Medical College

  collaborator OTHER

• Chengdu University of Traditional Chinese Medicine

  collaborator OTHER

• Mianyang Central Hospital

  collaborator OTHER

• People's Hospital of Deyang City

  collaborator UNKNOWN

• The First People's Hospital of Ziyang

  collaborator UNKNOWN

• Jiangyou People's Hospital

  collaborator UNKNOWN

• Science and Technology Department of Sichuan Province

  collaborator OTHER

• National Natural Science Foundation of China

  collaborator OTHER_GOV

• West China Hospital

  lead OTHER

Principal Investigators

• Ming Liu, MD · West China Hospital

• Shihong Zhang, MD · West China Hospital

• Simiao Wu, MD, PhD · West China Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-09-12

Primary Completion

2019-12-31

Completion

2020-08-31

Countries

• China

Study Locations