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Endogenous Lithium Clearance in Acute Kidney Injury

NCT05982340 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2025-06-22

No results posted yet for this study

Summary

Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness.

Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.

Conditions

  • Acute Kidney Injury Due to Sepsis
  • Proximal Tubule Function
  • Lithium Clearance

Interventions

DIAGNOSTIC_TEST

Lithium clearance

Blood and urine samples

Sponsors & Collaborators

  • University Hospital of North Norway

    lead OTHER

Principal Investigators

  • Lars MG Ytrebø, MD PhD · University Hospital of North Norway

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-01
Primary Completion
2025-05-20
Completion
2025-05-20

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05982340 on ClinicalTrials.gov