Clinical Study on Endoscopic Management of GOV1 Esophagogastric Varices

Summary

The patients with GOV1 esophagogastric varices will be treated with gastric variceal tissue gel injection, at the same time, the esophageal varices were treated with ligation, sclerotherapy, or no treatment. A new method for the treatment of esophageal varices will be proposed to improve the effective rate and reduce the recurrence rates and mortality, shorter hospital stays, and lower treatment costs, while further expanding HVPG testing to develop the best strategy for secondary prevention of endoscopic treatment in patients with GOV1 type esophageal and gastric varices.

Conditions

• Esophageal and Gastric Varices

Interventions

PROCEDURE

Endoscopic gel embolization of gastric fundus varices and ligation of esophageal varices

For patients with GOV1 esophagogastric varices, gastric varices will be treated with endoscopic gelatinous embolization, esophageal varices will be treated with ligation.

PROCEDURE

Endoscopic gel embolization of gastric fundus varices and sclerotherapy of esophageal varices

For patients with GOV1 esophagogastric varices, gastric varices will be treated with endoscopic gelatinous embolization, esophageal varices will be treated with sclerotherapy.

PROCEDURE

Endoscopic gelatinous embolization of gastric varices (esophageal varices not treated)

For patients with GOV1 esophagogastric varices, only gastric varices will be treated with endoscopic gelatinous embolization, esophageal varices will not be treated.

Sponsors & Collaborators

• Jinhua Hospital Affiliated to Zhejiang University

  collaborator UNKNOWN

• Lanxi People's Hospital

  collaborator OTHER

• Lishui Country People's Hospital

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  lead OTHER

Principal Investigators

• Wei Li, Master · 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

• Liangjing Wang, Doctor · 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-12-31

Primary Completion

2025-06-30

Completion

2025-11-30