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Stimulant Overdose in the Medicaid Population: Who is at Risk, and When Are They at Risk

NCT05976984 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 634939

Last updated 2025-09-22

No results posted yet for this study

Summary

This project addresses Objective 2 of RFA-CE-21-002: to assess risk and protective factors for illicit stimulant use, use disorder, or overdose that can contribute to the development or adaptation of intervention strategies. The study will 1) develop and validate a model using both person-level and area-level characteristics to identify, among Medicaid enrollees age 15 and older, who is at highest risk of an inpatient hospitalization or emergency department (ED) encounter for overdose from cocaine or other stimulants; 2) develop and validate a model to identify, among those Medicaid enrollees age 15 and older at highest risk of an inpatient hospitalization or ED encounter for stimulant overdose, when they are at highest risk; and 3) among those Medicaid enrollees age 15 and above with a prior inpatient hospitalization or ED encounter for stimulant overdose, to measure the rate of and identify risk and protective factors for a subsequent inpatient hospitalization or ED encounter for overdose from stimulants and/or opioids.

Conditions

  • Stimulant Overdose

Interventions

OTHER

Aim 1 (case-cohort study)

* Cases: All Medicaid enrollees age 15 years or older with at least one inpatient hospitalization or emergency department visit indicating a stimulant overdose during 2016-2020 * Subcohort: A random sample of all Medicaid enrollees age 15 years or older irrespective of their stimulant overdose history during 2016-2020

OTHER

Aim 2 (case-crossover study)

* Case period: 60 days before the date of stimulant overdose through the day before the date of stimulant overdose * Control period: 179 days before the date of stimulant overdose through 120 days before the date of stimulant overdose * Washout period: 119 days before the date of stimulant overdose through 61 days before the date of stimulant overdose

OTHER

Aim 3 (cohort study)

All Medicaid enrollees age 15 years or older with at least one inpatient hospitalization or emergency department visit indicating a stimulant overdose during 2016-2020

Sponsors & Collaborators

Principal Investigators

  • Sean Hennessy, PhD · University of Pennsylvania

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-30
Primary Completion
2022-11-16
Completion
2025-08-18

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05976984 on ClinicalTrials.gov