XPO-1 in Combination With RCHOP for DH/TH Lymphoma
NCT05974085 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2023-08-03
Summary
The purpose of this study was to evaluate the efficacy and safety of Selinexor in combination with RCHOP in first-line treatment of patients with DH or TH lymphoma.
Conditions
- Double Hit Lymphoma
- Triple Hit Lymphoma
Interventions
- DRUG
-
Selinexor+RCHOP
XPO-1 inhibitor selinexor in combination with RCHOP
Sponsors & Collaborators
-
Zhejiang Cancer Hospital
lead OTHER
Principal Investigators
-
Cong Li · Zhejiang Cancer Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-08-01
- Primary Completion
- 2023-12-31
- Completion
- 2024-03-01
Countries
- China
Study Locations
More Related Trials
-
Efficacy and Safety Study of Selinexor in Relapsed or Refractory Peripheral T-cell Lymphoma or Cutaneous T-cell Lymphoma
NCT02314247 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT04442022 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
A Phase Ib Study of Oral Selinexor in Adult Patients With Relapsed/Refractory B-cell Lymphoma Receiving R-DHAOx or R-GDP
NCT02741388 ·Status: COMPLETED ·Phase: PHASE1
-
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCT02227251 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy
NCT03193437 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Selinexor in Combination With Backbone Treatments or Novel Therapies In Participants With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)
NCT04607772 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma
NCT04640779 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Selinexor in Combination With MTX+Ritu to Treat R/R CNSL
NCT05698147 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma
NCT07011056 ·Status: RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of XTD Regimen (Selinexor, Thalidomide and Dexamethasone) in Adult Patients With Relapsed/Refractory LCH
NCT07204041 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase I Trial of Selinexor (KPT-330) and Ifosfamide, Carboplatin, Etoposide (ICE) in Peripheral T-cell Lymphoma
NCT03212937 ·Status: COMPLETED ·Phase: PHASE1
-
Selinexor, Anti-PD-1 Antibody and P-GemOx Regimen in R/R NKTCL
NCT06573151 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation
NCT02138786 ·Status: TERMINATED ·Phase: PHASE2
-
Efficacy and Safety of SHR0302 in Patients With Relapsed/Refractory Peripheral T/NK Cell Lymphoma
NCT05900089 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of Selinexor in Combination With Temozolomide and Anti-PD-1 Antibody in Patients With Relapsed/Refractory Primary Central Nervous System Lymphoma
NCT06556199 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Assess Safety and Efficacy of CHO-H01 as a Single Agent/Combined With Lenalidomide in Subjects With Refractory or Relapsed Non-Hodgkin's Lymphoma
NCT05950165 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma
NCT02471911 ·Status: COMPLETED ·Phase: PHASE1
-
Selinexor, Anti-PD-1 Antibody Plus Golidocitinib in R/R NKTCL
NCT06573138 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Study to Evaluate Efficacy and Tolerance of R-GemOx in DLBCL and MCL
NCT01562977 ·Status: COMPLETED ·Phase: PHASE2
-
PD-1 Inhibitor or PD-1 Inhibitor Plus GVD for Relapsed/Refractory CHL
NCT04624984 ·Status: UNKNOWN ·Phase: PHASE2
-
PXD101 and 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma
NCT00354185 ·Status: TERMINATED ·Phase: PHASE1
-
Selinexor and Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Aggressive Non-Hodgkin Lymphoma
NCT02303392 ·Status: COMPLETED ·Phase: PHASE1
-
Phase 1 Dose Finding Study of Belinostat for Treatment of Patients With Peripheral T-cell Lymphoma (PTCL)
NCT01839097 ·Status: COMPLETED ·Phase: PHASE1
-
SPEL as Introductive Treatment Following Immune-chemotherapy as Consolidated Therapy for R/R DLBCL With p53 and/or c-Myc Expression
NCT05498636 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase II Study of Linperlisib (YY-20394) in Patients With Relapsed or Refractory Peripheral T/NK Cell Lymphoma
NCT05274997 ·Status: UNKNOWN ·Phase: PHASE2