At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Summary

This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Currently most drug-related cancer care is conducted in infusion centers or specialty hospitals, where patients spend many hours a day isolated from family, friends, and familiar surroundings. This separation adds to the physical, emotional, social, and financial burden for patients and their families. The logistics and costs of navigating cancer treatments have become a principal contributor to patients' reduced quality of life. It is therefore important to reduce the burden of cancer in the lives of patients and their caregivers, and a vital aspect of this involves moving beyond traditional hospital and clinic-based care and evaluate innovative care delivery models with virtual capabilities. Providing cancer treatment at-home, versus in the clinic, may help reduce psychological and financial distress and increase treatment compliance, especially for marginalized patients and communities.

Conditions

• Advanced Anal Carcinoma
• Advanced Biliary Tract Carcinoma
• Advanced Bladder Carcinoma
• Advanced Breast Carcinoma
• Advanced Carcinoid Tumor
• Advanced Cervical Carcinoma
• Advanced Colorectal Carcinoma
• Advanced Gastric Carcinoma
• Advanced Glioblastoma
• Advanced Head and Neck Carcinoma
• Advanced HER2 Positive Breast Carcinoma
• Advanced Lung Carcinoma
• Advanced Lung Small Cell Carcinoma
• Advanced Malignant Germ Cell Tumor
• Advanced Malignant Solid Neoplasm
• Advanced Neuroendocrine Carcinoma
• Advanced Ovarian Carcinoma
• Advanced Pancreatic Carcinoma
• Advanced Prostate Small Cell Neuroendocrine Carcinoma
• Advanced Prostate Carcinoma
• Hematopoietic and Lymphoid System Neoplasm
• Multiple Myeloma
• Myelodysplastic Syndrome
• Advanced Basal Cell Carcinoma
• Advanced Cholangiocarcinoma
• Advanced Endometrial Carcinoma
• Advanced Esophageal Carcinoma
• Advanced Fallopian Tube Carcinoma
• Advanced Hepatocellular Carcinoma
• Advanced Liver Carcinoma
• Advanced Lymphoma
• Advanced Malignant Testicular Neoplasm
• Advanced Melanoma
• Advanced Merkel Cell Carcinoma
• Advanced Penile Carcinoma
• Advanced Primary Malignant Central Nervous System Neoplasm
• Advanced Renal Cell Carcinoma
• Advanced Sarcoma
• Advanced Skin Squamous Cell Carcinoma
• Advanced Urethral Carcinoma
• Advanced Vaginal Carcinoma
• Advanced Vulvar Carcinoma
• Advanced Appendix Carcinoma
• Advanced Gastroesophageal Junction Adenocarcinoma

Interventions

PROCEDURE

Clinical Encounter

Receive treatment in clinic

OTHER

Home Health Encounter

Receive at-home treatment

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

Sponsors & Collaborators

• Mayo Clinic

  lead OTHER

Principal Investigators

• Roxana S. Dronca, MD · Mayo Clinic

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-08-23

Primary Completion

2027-01-01

Completion

2027-01-01

Countries

• United States

Study Locations