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Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

NCT05961800 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-07-29

No results posted yet for this study

Summary

This study examines the relationship between central nervous system (CNS) mechanisms of pain inhibition and the pain relief that occurs following a lumbar medial branch block (MBB).

Conditions

  • Pain, Chronic
  • Facet Joint Pain
  • Pain, Procedural
  • Analgesia

Interventions

BEHAVIORAL

Cutaneous Probe

A computer-controlled probe delivers temperatures to the skin to measure pain, offset analgesia and onset hyperalgesia.

BEHAVIORAL

Quantitative Sensory Testing

Standard methods involving pinprick, pressure, heat, and cold applied to the skin are used to measure sensation and pain

BEHAVIORAL

Computer Tasks

Quantitative Sensory Testing (QST) and computer tasks are used to measure changes in pain intensity.

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Benedict J Alter, MD, PhD · University of Pittsburgh

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-05
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05961800 on ClinicalTrials.gov