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China Antihypertensive Trial for Intracranial Aneurysm (ChATIA-1)

NCT05941377 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 577

Last updated 2026-04-07

No results posted yet for this study

Summary

The goal of this randomized controlled trial is to evaluate the benefits and safety of controlled hypotension in Chinese patients with unruptured intracranial aneurysms(UIA).

The main questions it aims to answer are:

* To provide high-level evidence of the benefits and safety of controlled hypotension in patients with UIA.
* To provide evidence-based medical evidence for blood pressure control of patients with UIA in neurosurgery, and promote the progress of accurate individual management of patients. In this study, the main intervention is enhanced blood pressure lowering in patients with UIA.

All Patients will be randomly assigned to either the standard blood pressure lowering (SBPL) group or the enhanced blood pressure lowering (EBPL) group.

Conditions

  • Unruptured Intracranial Aneurysm

Interventions

OTHER

blood pressure lowering

For EBPL group, patients are required to keep blood pressure at 100-120 mmHg. For SBPL group, patients are required to keep blood pressure at 120-140 mmHg.

Sponsors & Collaborators

  • RenJi Hospital

    collaborator OTHER

  • Guangzhou Red Cross Hospital

    collaborator OTHER

  • Jiangnan University Medical Center

    collaborator UNKNOWN

  • Binzhou Medical University

    collaborator OTHER

  • Beijing Friendship Hospital

    collaborator OTHER

  • Beijing Chao Yang Hospital

    collaborator OTHER

  • Beijing Anzhen Hospital

    collaborator OTHER

  • First Affiliated Hospital of Fujian Medical University

    collaborator OTHER

  • Beijing Tiantan Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-01
Primary Completion
2026-01-19
Completion
2026-01-19

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05941377 on ClinicalTrials.gov