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Safety and Efficacy of Ultrasound Renal Denervation in Kidney Transplantation Patients With Uncontrolled Hypertension

NCT05934383 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-06-26

No results posted yet for this study

Summary

This prospective, single-arm, interventional study is designed to assess the short-term and long-term safety and efficacy of bilateral ultrasound renal sympathetic denervation (RDN) of the native kidneys in renal transplant patients with uncontrolled hypertension.

Objectives:

* To assess the short-term and long-term changes in ambulatory and office blood pressure (BP) following native kidney RDN in renal transplant patients
* To assess the long-term safety of native kidney RDN in renal transplant patients
* To assess the short-term and long-term change in antihypertensive drug prescriptions following native kidney RDN in renal transplant patients
* To assess the short-term and long-term change in adherence to antihypertensive drugs following native kidney RDN in renal transplant patients

Conditions

Interventions

DEVICE

Paradise® ultrasound renal denervation system.

Bilateral renal sympathetic denervation of the native kidneys using the Paradise® ultrasound renal denervation system.

Sponsors & Collaborators

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-04
Primary Completion
2026-01-31
Completion
2030-09-30

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05934383 on ClinicalTrials.gov