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Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

NCT05912881 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2026-02-18

No results posted yet for this study

Summary

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Conditions

  • Anosmia
  • Skull Base Neoplasms

Interventions

OTHER

Olfactory training

Participants perform olfactory training using sticks filled with scented essential oils.

OTHER

Placebo training

Participants perform olfactory training using sticks filled with unscented medium chain triglycerides.

Sponsors & Collaborators

Principal Investigators

  • Nicholas Rowan, MD · Johns Hopkins School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2026-01-01
Completion
2026-01-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05912881 on ClinicalTrials.gov