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Predicting Lung Cancer-Associated Cachexia With PET Imaging

NCT05912465 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2023-06-27

No results posted yet for this study

Summary

This prospective observational study aims to investigate the relationship between cancer cachexia, stress levels, and metabolic changes in 150 lung cancer patients. Cancer cachexia, characterized by weight loss and muscle wasting, significantly impacts patient outcomes. Psychological stress is thought to contribute to cachexia development. Assessments will include medical history, physical examinations, laboratory tests, and imaging. Cancer cachexia will be diagnosed based on weight loss, reduced food intake, and inflammation markers. Psychological stress will be evaluated using questionnaires and biomarkers. Metabolic changes will be assessed using positron emission tomography-computed tomography (PET-CT) scans. The primary objective is to determine differences in metabolic activity between cachectic and non-cachectic patients. Secondary objectives include evaluating changes in brain activity and exploring the relationship between stress, inflammation, and metabolism.

Conditions

  • Cachexia
  • Lung Neoplasm

Interventions

OTHER

Stress Reduction Training

A subgroup of patients from Vienna will undergo an additional PET/CT scan after the first follow-up PET/CT, which takes place one month after stress reduction training. The stress reduction training involves performing a breathing technique.

Sponsors & Collaborators

  • University of Leipzig

    collaborator OTHER

  • Careggi Hospital

    collaborator OTHER

  • University of Copenhagen

    collaborator OTHER

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Marcus Hacker, Prof. · Medical University of Vienna, Department of Radiology and Nuclear Medicine

  • Thomas Beyer, Prof. · Medical University of Vienna, Center for Medical Physics and Biomedical Engineering

  • Osama Sabri, Prof. · University of Leipzig Medical Center

  • Roberto Sciagrà, Prof. · Careggi University Hospital

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-01
Primary Completion
2024-07-01
Completion
2025-03-01

Countries

  • Austria
  • Germany
  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05912465 on ClinicalTrials.gov