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Brown Adipose Tissue Activity and Energy Metabolism in Cachexia

NCT02500004 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2018-08-03

No results posted yet for this study

Summary

To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.

Conditions

  • Cachexia
  • Neoplasms
  • Pulmonary Disease, Chronic Obstructive
  • Pancreatic Neoplasms

Interventions

RADIATION

18F-FDG PET-MRI-imaging

BAT activity: 18F-FDG PET-MRI-imaging.

RADIATION

DXA scanning

Body composition: DXA scanning, D2O and MRI.

PROCEDURE

Abdominal subcutaneous adipose tissue biopsy

Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

PROCEDURE

Blood sampling

Systemic inflammatory profile: blood sampling.

OTHER

Indirect calorimetry

Resting metabolic rate: indirect calorimetry.

DEVICE

Accelerometry

Physical activity level: accelerometry.

OTHER

Double-labeled water

Body composition: DXA scanning, D2O and MRI. Total daily energy expenditure: double-labeled water.

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Annemie Schols, PhD · Maastricht UMC

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2018-07-31
Completion
2018-07-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02500004 on ClinicalTrials.gov