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Investigation of the Efficacy of Metformin Therapy on Pulmonary Sarcoidosis

NCT05910554 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2025-02-11

No results posted yet for this study

Summary

This is a double blinded, randomized, placebo controlled clinical trial of 40 participants with pulmonary sarcoidosis.

Primary Objective: To assess the steroid-sparing efficacy and safety of oral metformin therapy in participants with confirmed progressive pulmonary sarcoidosis for participants with steroid dependent disease.

Conditions

  • Sarcoidosis, Pulmonary

Interventions

DRUG

Metformin

Patients randomized to metformin will be assigned the active arm.

DRUG

Cellulose

Patients randomized to cellulose will be assigned the placebo arm.

Sponsors & Collaborators

  • University of Maryland, Baltimore

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-10
Primary Completion
2027-06-01
Completion
2027-09-01
FDA Drug
Yes

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Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05910554 on ClinicalTrials.gov