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Decision Making in Chronic Pain and Alcohol Use Disorder

NCT05901610 · Status: SUSPENDED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-02-03

No results posted yet for this study

Summary

The objective of this within-subject study is to test the effects of Episodic Future Thinking (EFT) and Low-intensity Focused Ultrasound (LIFU) interventions on the pain of subjects who have chronic pain and alcohol use disorder(s).

Conditions

Interventions

BEHAVIORAL

Episodic Future Thinking

Participants will generate descriptions of vivid positive future events.

BEHAVIORAL

Control Episodic Thinking

Participants will generate descriptions of vivid positive past events.

DEVICE

Low-intensity Focused Ultrasound

A transducer device will use focused ultrasound energy to neuromodulate the insular cortex. The participant's brain will be mapped based on information from the CT and MRI scans, and the transducer will deliver brief ultrasound pulses to the insular cortex.

DEVICE

Sham Low-intensity Focused Ultrasound

All of the same actions done during LIFU will be performed, but the device will be inactive.

Sponsors & Collaborators

  • Virginia Polytechnic Institute and State University

    lead OTHER

Principal Investigators

  • Wynn Legon, PhD · Virginia Polytechnic and State University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-28
Primary Completion
2026-06-30
Completion
2026-06-30
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05901610 on ClinicalTrials.gov