MEDI5752 in Patients With Mature Tertiary Lymphoid Structures Solid Tumors.
NCT05888857 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 102
Last updated 2025-08-13
Summary
Multicentric, prospective, multi-indication, single-treatment arm, open-label phase II trial assessing the efficacy of MEDI5752
Conditions
- Advanced Solid Tumor
Interventions
- DRUG
-
MEDI5752
A treatment cycle consists of 3 weeks. MEDI5752 will be administered by intravenous infusion at a fixed dose on Day 1 of each cycle
Sponsors & Collaborators
-
National Cancer Institute, France
collaborator OTHER_GOV - collaborator INDUSTRY
-
Institut Bergonié
lead OTHER
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-09-30
- Primary Completion
- 2026-03-31
- Completion
- 2028-09-30
Countries
- France
Study Locations
More Related Trials
-
Temozolomide in Treating Patients With Metastatic Non-small Cell Lung Cancer
NCT00006877 ·Status: COMPLETED ·Phase: PHASE2
-
Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid Tumors
NCT03982173 ·Status: WITHDRAWN ·Phase: PHASE2
-
MEDI4736 Combinations in Metastatic Renal Cell Carcinoma
NCT02819596 ·Status: COMPLETED ·Phase: PHASE2
-
ISIS 3521 in Treating Patients With Advanced, Unresectable, or Metastatic Non-small Cell Lung Cancer or Unresectable or Metastatic Melanoma
NCT00003989 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Trial of Neoadjuvant Temozolomide in Melanoma Patients With Palpable Stage III or IV Disease Undergoing Complete Surgical Resection
NCT00588341 ·Status: COMPLETED ·Phase: PHASE2
-
Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma
NCT02860286 ·Status: COMPLETED ·Phase: PHASE2
-
STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma
NCT00006357 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment
NCT04557956 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Cediranib Maleate in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery
NCT00309946 ·Status: COMPLETED ·Phase: PHASE2
-
Single-arm Trial to Evaluate the Biodistribution and Shedding of Talimogene Laherparepvec
NCT02014441 ·Status: COMPLETED ·Phase: PHASE2
-
Exploratory Study to Assess the Biological Activity of ZD6126 in Subjects With Newly Diagnosed Metastatic Renal Cell Carcinoma (Stage IV)
NCT00065572 ·Status: SUSPENDED ·Phase: PHASE2
-
Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer
NCT04919382 ·Status: RECRUITING ·Phase: PHASE2
-
Bortezomib in Treating Patients With Advanced or Metastatic Sarcoma
NCT00027716 ·Status: COMPLETED ·Phase: PHASE2
-
Selumetinib in Treating Patients With Locally Advanced or Metastatic Liver Cancer
NCT00604721 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies
NCT02937675 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Bortezomib in Treating Patients With Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy
NCT00104871 ·Status: COMPLETED ·Phase: PHASE2
-
Tazemetostat in Treating Patients With Metastatic or Unresectable Solid Tumors or B-Cell Lymphomas With Liver Dysfunction
NCT03217253 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
NCT06157892 ·Status: RECRUITING ·Phase: PHASE2
-
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic Malignant Melanoma
NCT00104897 ·Status: COMPLETED ·Phase: PHASE2
-
Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)
NCT04439357 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas
NCT05253131 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Study of AS1409 in Patients With Either Metastatic Renal Cell Carcinoma or Metastatic Malignant Melanoma
NCT00625768 ·Status: COMPLETED ·Phase: PHASE1
-
Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma
NCT00509041 ·Status: COMPLETED ·Phase: PHASE2
-
Tanespimycin in Treating Patients With Stage III-IV Melanoma
NCT00087386 ·Status: TERMINATED ·Phase: PHASE2
-
Phase 3 Study to Treat Patients With Soft Tissue Sarcomas
NCT02049905 ·Status: COMPLETED ·Phase: PHASE3