Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries

Summary

The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury. The main question :

• Does the combination of UCH-L1 and GFAP can exclude brain injuries detected with CT scan in the first twelve hours after a mild traumatic brain injury?

Participants will do the exams planed in routine care and :

* during the expected blood sampling an additional blood sample will be done,
* seven days after the discharge a call will be done by the investigator.

Conditions

• Traumatic Brain Injury

Interventions

OTHER

UCH-L1 GFAP

measurment of UCH-L1 GFAP within 12 hours in adult patients after a mild traumatic brain injury

Sponsors & Collaborators

• BioMérieux

  collaborator INDUSTRY

• Assistance Publique - Hôpitaux de Paris

  collaborator OTHER

• University Hospital, Clermont-Ferrand

  collaborator OTHER

• Hospices Civils de Lyon

  collaborator OTHER

• Poitiers University Hospital

  collaborator OTHER

• University Hospital, Angers

  collaborator OTHER_GOV

• Centre Hospitalier Universitaire de Nīmes

  collaborator OTHER

• Centre Hospitalier Universitaire de Nice

  collaborator OTHER

• Nantes University Hospital

  collaborator OTHER

• University Hospital, Montpellier

  collaborator OTHER

• Centre Hospitalier Universitaire Dijon

  collaborator OTHER

• University Hospital, Grenoble

  collaborator OTHER

• Fondation Hôpital Saint-Joseph

  collaborator OTHER

• CHU de Tours

  collaborator UNKNOWN

• Centre Hospitalier Princesse Grace

  lead OTHER

Principal Investigators

• Pierre HAUSFATER, MD-PhD · Assistance Publique - Hôpitaux de Paris

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-04-19

Primary Completion

2025-12-15

Completion

2026-03-30

Countries

• France
• Monaco

Study Locations