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Detecting Lung's Closing Pressure by Capnography

NCT05873998 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2025-05-16

No results posted yet for this study

Summary

General anesthesia is associated with loss of pulmonary functional residual capacity and the consequent development of atelectasis and closure of the small airway.

Mechanical ventilation in a lung with reduced functional residual capacity and atelectasis increased the dynamic alveolar stress-strain, inducing a local inflammatory response in atelectatic lung areas known as ventilatory-induced lung injury. This phenomenon may appear even in healthy patients undergoing general anesthesia and predisposes them to hypoxemic episodes that can persist in the early postoperative period.

Lung recruitment maneuvers restore the functional residual capacity and, therefore, protect the lungs from lung injury. A key issue in this kind of treatment is detecting the lung's closing pressure in order to maintain the end-expiratory pressure above such a limit.

Conditions

  • Atelectasis

Interventions

DIAGNOSTIC_TEST

Slow pressure-volume curve

Patients will be sequentially subjected to a slow pressure-volume curve and a lung recruitment maneuver

Sponsors & Collaborators

  • Hospital Privado de Comunidad de Mar del Plata

    lead OTHER

Principal Investigators

  • Nora Fuentes, PhD · Hospital Privado de Comunidad

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-28
Primary Completion
2025-05-01
Completion
2025-05-10

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05873998 on ClinicalTrials.gov