Evaluation of the Usefulness of Echocardiography in Patients With Staphylococcus Aureus Bacteremia (ET-AUREUS Study).

Summary

The goal of this prospective interventionist cohort study is to assess the prevalence of infective endocarditis in patients with Staphylococcus aureus bacteremia at low risk of this complication.

The main questions it aims to answer are:

* Determine whether the risk of infective endocarditis in patients with Staphylococcus aureus bacteriemia identified as low-risk, using the VIRSTA score, is low enough to safely omit transthoracic or transesophageal echocardiography.
* Determine whether the risk of infective endocarditis in patients with Staphylococcus aureus bacteriemia in patients with no identifiable risk factor is low enough to safely omit transthoracic or transesophageal echocardiography.
* Calculate a cost-benefit estimate of omitting echocardiographic testing in patients identified as low-risk by means of the above methods.

Participants will undergo mandatory transthoracic and transesophageal echocardiography during the first 2 weeks from Staphylococcus aureus bacteremia onset.

Conditions

• Staphylococcus Aureus Bacteremia
• Infective Endocarditis

Interventions

DIAGNOSTIC_TEST

Echocardiography evaluation

Patients will undergo mandatory transthoracic echocardiography during assessment of Staphylococcus aureus bacteremia. Later, they will also undergo mandatory transesophageal echocardiography. Both test will be performed during the first 14 days from bacteremia onset.

Sponsors & Collaborators

• Hospital Rafael Mendez

  collaborator UNKNOWN

• Gregorio Marañón Hospital

  collaborator OTHER

• University Hospital Virgen de las Nieves

  collaborator OTHER

• Hospital Universitario La Paz

  collaborator OTHER

• Hospital Mutua de Terrassa

  collaborator OTHER

• Hospital Universitario Virgen de la Arrixaca

  collaborator OTHER

• Hospital Infanta Sofia

  collaborator OTHER

• Hospitales Universitarios Virgen del Rocío

  collaborator OTHER

• Hospital de Alava

  collaborator UNKNOWN

• Hospital de Donosti

  collaborator UNKNOWN

• Hospital de Basurto

  collaborator OTHER

• Hospital Universitario Virgen Macarena

  collaborator OTHER

• Hospital Santa Cruz de Tenerife

  collaborator UNKNOWN

• Puerta de Hierro University Hospital

  lead OTHER

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-09-04

Primary Completion

2025-09-01

Completion

2025-12-31

Countries

• Spain

Study Locations