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Staphylococcus Aureus Caught in Action at the Site of Infection

NCT04781569 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-06-03

No results posted yet for this study

Summary

This study is to obtain a comprehensive view of S. aureus adaptations in the infected human host and (i) to improve the understanding of the interface between antibiotic therapy, resistance development and virulence factor adaptation in S. aureus infected patients, and (ii) to adapt these findings into a more sustainable use of antimicrobials for therapy.

Conditions

  • Staphylococcus (S.) Aureus Infection

Interventions

OTHER

data collection

Health-related personal data such as year of birth, sex, Body Mass Index (BMI), infection classification, concomitant infections, comorbidities according to medical chart, standard diagnostic markers (CRP, blood differential plots, creatinine, ...), medication, treatment start, treatment end and discharge from hospital will be collected.

DIAGNOSTIC_TEST

blood draw

2 blood drawing events (in total 22.5 ml) will be performed in the patient. 1 blood drawing events will be performed in the healthy proband.

DIAGNOSTIC_TEST

nose swabs

2 nose swabs will be taken in the patient. 1 nose swab will be performed in the healthy proband.

DIAGNOSTIC_TEST

Intraoperative tissue samples

Intraoperative tissue samples from the site of infection during surgery will be taken in the patient.

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Nina Khanna, PD Dr. med. · University Hospital, Basel, Switzerland

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-06
Primary Completion
2020-11-23
Completion
2020-11-23

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04781569 on ClinicalTrials.gov