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Real-time Motion Management During Prostate and Lung Radiotherapy

NCT05844761 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 132

Last updated 2025-05-21

No results posted yet for this study

Summary

The goal of this interventional non-inferiority trial is to assess the accuracy of different real-time motion management radiotherapy techniques. The main question the study aims to answer are:

* What are the target margins for radiotherapy with motion management that are not inferior to target margin without motion management
* What are the dosimetric and geometrical accuracy to patient for the motion management techniques.

Participants will answer QoL questionary, and the accuracy of treatment will be assessed from treatment data.

Conditions

  • Cancer of Lung
  • Lung Metastasis
  • Cancer of Prostate

Interventions

RADIATION

Triggered imaging on TrueBeam with margin reduction

At interim analysis the Planning target volume (PTV) will be reduced based on the accuracy of the TrueBeam triggered imaging motion management technique.

RADIATION

Synchrony MLC tracking on fiducials with margin reduction

At interim analysis the Planning target volume (PTV) will be reduced based on the accuracy of the Radixact Synchrony motion management technique.

RADIATION

Synchrony MLC tracking and lung adaptive model with margin reduction

At interim analysis the Planning target volume (PTV) will be reduced based on the accuracy of the Radixact Synchrony motion management technique for lung cancer.

Sponsors & Collaborators

  • Region Skane

    lead OTHER

Principal Investigators

  • André Haraldsson, PhD, MPE · Skane university hospital, Lund university

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-01
Primary Completion
2026-05-31
Completion
2026-12-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05844761 on ClinicalTrials.gov