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Tracking of Respiratory-Induced Tumor Motion Using Implanted Fiducials

NCT00500513 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2013-02-01

No results posted yet for this study

Summary

Objectives:

* To determine the safety of fiducial implantation.
* To determine the extent/rate of migration of radio-opaque fiducials placed in lung tumors and adjacent normal tissue.
* To compare real-time portal imaging-based fiducial tracking with measurement of three-dimensional motion by four-dimensional CT scanning to determine how many fiducials are needed to track a tumor.
* To determine if intra-fractional lung tumor motion changes during a course of treatment, and when during the treatment this occurs.
* To correlate the position of internal fiducials with the position of the external patient surface during respiration.
* To quantify the residual motion of the clinical target volume during radiotherapy gated using external fiducials.
* To verify the adequacy of the treatment portal margins in encompassing the residual motion of the clinical target volume.
* To determine if radio-opaque fiducial placement adjacent to the trachea (which does not move) can reduce daily setup inaccuracies, and so spare normal tissue.
* To determine the motion of hilar adenopathy (if any), and whether it correlates with motion of the primary tumor.

Conditions

Interventions

PROCEDURE

CT Scans

CT scan performed weekly to measure how much the tumor moves + additional pulmonary function measurements.

PROCEDURE

Implanted markers

Implanted radio-opaque fiducial markers, diameter of 1.0 - 2.0 mm, inserted through a catheter at several chest locations using a flexible bronchoscope

RADIATION

Radiation Treatment (RT)

Radiotherapy incorporating respiratory treatment delivery

Sponsors & Collaborators

  • M.D. Anderson Cancer Center

    lead OTHER

Principal Investigators

  • George Starkschall, PhD · M.D. Anderson Cancer Center

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-04-30
Primary Completion
2007-06-30
Completion
2011-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00500513 on ClinicalTrials.gov