Rhythmic Auditory Stimulation on Neural Activity During Finger-tapping in PD Patients

Summary

Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. The investigators will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine real-time neural activity when patients with PD and healthy controls listen to RAS and execute finger-tapping task simultaneously.

Methods and analysis This study will recruit patients with PD and healthy controls. Electroencephalography (EEG) will be used under six conditions related to a finger-tapping task. Two-way repeated measures analysis of variance will be performed to investigate the group and condition effects on neural mechanisms.

Study significance This study will offer evidence on RAS effects and mechanisms by investigating the changes in upper-limb movements and neural mechanisms during auditory-motor entrainment. Results from this study will provide a solid foundation for further research and clinical applications of RAS.

Conditions

• Acoustic Stimulation
• Parkinson Disease
• Electroencephalography

Interventions

BEHAVIORAL

noF-noRAS

resting state, that is, without finger-tapping and without listening to RAS

BEHAVIORAL

F-noRAS

finger-tapping without listening to RAS

BEHAVIORAL

noF-100RAS

listening to RAS with the 100% of the baseline tempo and without finger-tapping

BEHAVIORAL

F-100RAS

finger-tapping and listening to RAS with 100 % of baseline tempo

BEHAVIORAL

F-105RAS

finger-tapping and listening to RAS with 105 % of baseline tempo

BEHAVIORAL

F-110RAS

finger-tapping and listening to RAS with 110 % of baseline tempo

Sponsors & Collaborators

• The Hong Kong Polytechnic University

  lead OTHER

Principal Investigators

• Wei FAN (PhD student), MSc · Rehabilitation Sciences

Eligibility

Min Age

18 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-06-01

Primary Completion

2026-03-31

Completion

2026-03-31