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Mechanisms of Open and Hidden Placebo in Stroke Recovery

NCT05832567 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 56

Last updated 2025-09-17

No results posted yet for this study

Summary

This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.

Conditions

Interventions

DEVICE

Active rTMS

Subjects will undergo repetitive transcranial magnetic stimulation, each session lasting 20 minutes.

DEVICE

Sham rTMS

Subjects will undergo sham repetitive transcranial magnetic stimulation, each session lasting 20 minutes.

DIETARY_SUPPLEMENT

Open Placebo

The open placebo will consist of an inactive substance pill commonly used in clinical trials and given to the subject in a regular pill dispenser.

Sponsors & Collaborators

  • Spaulding Rehabilitation Hospital

    lead OTHER

Principal Investigators

  • Felipe Fregni, MD, PhD, MPH · Spaulding Rehabilitation Hospital/Harvard Medical School

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-11
Primary Completion
2026-06-01
Completion
2026-06-30
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05832567 on ClinicalTrials.gov