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Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors

NCT05831631 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-06-11

No results posted yet for this study

Summary

The goal of this observational study is to characterize the circulating leukocyte profile and the immune T cells distribution within the tumor in patients with malignant brain tumors and to correlate these findings with the oncological outcome.

Participants will be subjected to blood sampling before surgery and for 12 months of follow-up. Additional sampling and analysis will be performed on tumor samples.

Conditions

  • Brain Tumor, Primary
  • Brain Tumor - Metastatic

Interventions

DIAGNOSTIC_TEST

Circulating leukocytes immunophenotype

Blood samples will be tested with flow cytometry in order to characterize leukocyte subpopulations and to evaluate the circulating immunophenotype

DIAGNOSTIC_TEST

Tumor sampling

Immunohistochemical analysis will be performed on tumor samples in order to characterize immune T cells distribution within the tumor.

Sponsors & Collaborators

  • Pietro Mortini, MD, Prof.

    lead OTHER

Principal Investigators

  • Pietro Mortini, MD, Prof. · IRCCS San Raffaele Scientific Institute

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-01
Primary Completion
2028-07-31
Completion
2029-08-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05831631 on ClinicalTrials.gov