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Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis

NCT05827562 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2023-04-25

No results posted yet for this study

Summary

To evaluate the changes in the frequencies of circulating CD4+ and CD4- T cells expressing CD8αα and CD8αβ in peripheral blood of RA patients in comparison with healthy controls. Also, to correlate circulating and synovial fluid levels of these cells with disease activity score (DAS28) and other indices of disease severity.

Conditions

Interventions

DIAGNOSTIC_TEST

flow cytometry

Levels of circulating and synovial fluid CD4+ and CD4- T cells expressing CD8αα and CD8αβ will be assessed by flow cytometry using fluorochrome-labelled monoclonal antibodies against CD3, CD4, CD8α and CD8β surface markers. Levels of the following cells will be assessed: 1. CD3+CD4-CD8αα+ 2. CD3+CD4-CD8α+CD8βlow 3. CD3+CD4-CD8α+CD8βhigh 4. CD3+CD4+CD8αβhigh 5. CD3+CD4+CD8αα+

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-01
Primary Completion
2025-11-30
Completion
2025-12-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05827562 on ClinicalTrials.gov