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Bladder and Bone Effects of Pelvic Radiation Therapy in Childhood Cancer Survivors

NCT05818462 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2026-01-29

No results posted yet for this study

Summary

The aim of this study is to measure and evaluate the effects of pelvic external beam radiation therapy (EBRT) on lower urinary tract (LUT) function and bone mineralization.

Conditions

Interventions

DIAGNOSTIC_TEST

Uroflow testing

Uroflowmetry is a test that measures the volume of urine released from the body, the speed with which it is released, and how long the release takes.

DIAGNOSTIC_TEST

Bladder Scan

Bladder scan measures ultrasonic reflections within the patient's body to differentiate the urinary bladder from the surrounding tissue. In this case, it is used to detect the volume of urine in the bladder.

OTHER

Dysfunctional Voiding Scoring System Survey

The Dysfunctional Voiding Symptom Score to provide accurate and objective numerical, grading of voiding behaviors of children.

DIAGNOSTIC_TEST

DEXA Scan of pelvis and sacral spine

DEXA (dual x-ray absorptiometry) scans measure bone density (thickness and strength of bones) by passing a high and low energy x-ray beam (a form of ionizing radiation) through the body, usually in the hip and the spine.

DIAGNOSTIC_TEST

Urine tests for specific biomarkers

Urine tests for specific biomarkers (ATP, NGF, BNDF and urine proteomic screening).

Sponsors & Collaborators

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Michael Edwards, MD · Children's Hospital Colorado

Eligibility

Min Age
2 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-11
Primary Completion
2025-05-02
Completion
2025-05-02

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05818462 on ClinicalTrials.gov