MedTrace Logo

Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial

NCT05816850 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 654

Last updated 2025-12-29

No results posted yet for this study

Summary

This is a Multicenter, Retrospective, Biological study ancillary to FOLL12 trial to evaluate the role of EZH2 aberrations in patient with FL treated with immunochemotherapy. Moreover, several novel biomarkers of FL will be investigated.

Conditions

Interventions

DIAGNOSTIC_TEST

EZH2 mutations/CNAs by droplet digital PCR (ddPCR)

Test of EZH2 mutations/CNAs by droplet digital PCR (ddPCR) in peripheral blood and in unsorted bone marrow aspirate samples at enrolment

DIAGNOSTIC_TEST

EZH2-derived gene expression signature by RNA-Seq

Test of EZH2-derived gene expression signature by RNA-Seq in a subset of diagnostic FFPE samples

Sponsors & Collaborators

  • Fondazione Italiana Linfomi - ETS

    lead OTHER

Principal Investigators

  • Simone Ferrero, MD · SC Ematologia U - AOU Città della Salute e della Scienza di Torino

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-19
Primary Completion
2026-12-01
Completion
2027-06-01

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05816850 on ClinicalTrials.gov