IMM2902 in Patients With Advanced Solid Tumors Expressing HER2
NCT05805956 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 105
Last updated 2023-04-10
Summary
This trial is an open-label, multicenter, first-in-human dose-escalation and cohort expansion Phase I/II clinical study to evaluate the safety, tolerability and preliminary efficacy of IMM2902 in the treatment of HER2-expressing advanced solid tumors
Conditions
- Advanced Solid Tumor
- Advanced Lung Cancer
- Advanced Gastric Carcinoma
- Advanced Cholangiocarcinoma
Interventions
- DRUG
-
IMM2902
a recombinant bispecific monoclonal antibody with high affinity to the dual targets, HER2 and CD47
Sponsors & Collaborators
-
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-02-15
- Primary Completion
- 2024-10-31
- Completion
- 2024-10-31
- FDA Drug
- Yes
Countries
- China
Study Locations
More Related Trials
-
A Phase I Study of SIM0686 in Participants With Locally Advanced/Metastatic Solid Tumors
NCT07050459 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Study Evaluating the Safety and Efficacy of Anti-HER2-CAR-T Cells Injection in Patients With Solid Tumors
NCT06101082 ·Status: RECRUITING ·Phase: PHASE1
-
Anti-HER2 CAR-T Cell Injection in Patients With HER2-positive Advanced Malignant Solid Tumors
NCT06658951 ·Status: RECRUITING ·Phase: NA
-
A Study of Safety, Tolerability and Pharmacokinetics of Nivolumab in Chinese Subjects With Previously Treated Advanced or Recurrent Solid Tumors
NCT02593786 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
IMM2520, a PD-L1 and CD47 Bispecific Antibody in Patients With Advanced Solid Tumors
NCT05780307 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of T3011 Administered Via Intratumoral Injection in Patients With Advanced Solid Tumors
NCT05602792 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Phase I Study of SIM0609 in Adult Participants With Locally Advanced/Metastatic Solid Tumors
NCT07265921 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of MRG002 in the Treatment of HER2-positive Unresectable Locally Advanced or Metastatic Urothelium Cancer
NCT04839510 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of FDA022-BB05 in Subjects With Advanced Solid Malignant Tumors
NCT05564858 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of IMC008 for Advanced Solid Tumors
NCT05837299 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of PM1022 in Patients With Advanced Tumors
NCT05867771 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of IMM2510 + IMM01 Combination Therapy in Patients With Advanced Solid Tumors
NCT07170787 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase Ib Study of Primary Efficacy and Safety of IBI321 Monotherapy or Combination Therapy in Patients With Advanced Solid Tumors
NCT05172856 ·Status: UNKNOWN ·Phase: PHASE1
-
Intratumoral CAN1012(selective TLR7 Agonist) in Subjects with Solid Tumors
NCT05580991 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
An Open-label Study of SG1827 in Subjects With Advanced Solid Tumors
NCT06076291 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Clinical Trial of IBC0966 in Patients With Advanced Malignant Tumors
NCT04980690 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Study of KN052 in Chinese Subjects With Advanced Solid Tumors
NCT05309512 ·Status: TERMINATED ·Phase: PHASE1
-
Pharmacokinetics Study of Nimotuzumab in Patients With Solid Tumors
NCT02395068 ·Status: UNKNOWN ·Phase: PHASE1
-
Clinical Study of ICP-192 in Solid Tumors Patients
NCT03758664 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of FDA022-BB05 in Advanced/Metastatic Solid Tumors
NCT06413615 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase III Randomized Study in CLDN18.2-positive Unresectable Locally Advanced Gastric Cancer Patients
NCT07103668 ·Status: RECRUITING ·Phase: PHASE3
-
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
NCT07066657 ·Status: RECRUITING ·Phase: PHASE1
-
A Phase I Trial of CCT303-406 in Patients With Relapsed or Refractory HER2 Positive Solid Tumors
NCT04511871 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Clinical Trial of BT02 in Patients With Advanced Solid Tumors
NCT06404905 ·Status: RECRUITING ·Phase: PHASE1
-
ZZ06 in Adult Patients With Advanced Solid Tumor Malignancies
NCT04412616 ·Status: RECRUITING ·Phase: PHASE1