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Biofilm Composition as a Predictive Biomarker for Prosthetic Joint Infection

NCT05804058 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2023-04-07

No results posted yet for this study

Summary

Prosthetic joint infection (PJI) represents one of the most common reasons for failure among hip and knee prostheses, with an incidence of around 1-2%. Infection can occur early (within days of surgery) or late (over a year after surgery), and no specific early markers for infection onset exist. Given the significant costs to the NHS for corrective revision surgery, the added suffering and risk to patients from surgery, and the risk of enhancing antimicrobial resistance through the use of broad-spectrum antibiotics, a more specific predictive test for early onset of infection is required.

Conditions

  • Joint Infection

Interventions

PROCEDURE

Revision surgery

Patients due to undergo prosthetic revision surgery for any reason (infection or aseptic)

Sponsors & Collaborators

  • University of Portsmouth

    collaborator OTHER

  • Portsmouth Hospitals NHS Trust

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2021-01-19
Completion
2021-01-19

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05804058 on ClinicalTrials.gov