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Effect of Encapsulated Vs Free Probiotic on Brain Function

NCT05801042 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 91

Last updated 2024-10-08

No results posted yet for this study

Summary

Aging is associated with changes in a wide variety of brain networks, including the default mode, saliency attention, and visual networks. Furthermore, current research suggests that a relationship exists between functional connectivity at rest and cognition. Lactocaseibacillus rhamnosus is an ideal strain for the intervention, as it has been show to affect the gut-brain axis, brain function, and behavior. Therefore, the investigators plan to assess resting state functional magnetic resonance imaging (fMRI) to compare changes in brain connectivity between the groups receiving the encapsulate and non-encapsulated Lactocaseibacillus rhamnosus supplements.

Conditions

  • Aging

Interventions

DIETARY_SUPPLEMENT

Maltodextrin

Placebo product

DIETARY_SUPPLEMENT

Encapsulated Lactocaseibacillus rhamnosus

Probiotic product

DIETARY_SUPPLEMENT

Non-encapsulated Lactocaseibacillus rhamnosus

Probiotic product

Sponsors & Collaborators

  • Robert Brummer

    lead OTHER

Principal Investigators

  • Robert JM Brummer, MD PhD · Örebro University, Sweden

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-07
Primary Completion
2023-11-10
Completion
2024-09-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05801042 on ClinicalTrials.gov