CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).

Summary

Multi-center, randomized, parallel-group, superiority study to compare the efficacy of adjunct intra-arterial rt-PA versus not adjunct intra-arterial rt-PA in the improvement of the efficacy of mechanical thrombectomy in patients with large vessel occlusion acute ischemic stroke.

Conditions

• Stroke, Acute Ischemic
• Stroke, Acute

Interventions

DRUG

Intraarterial alteplase

See arm/group descriptions.

Sponsors & Collaborators

• Hospital Clinic of Barcelona

  lead OTHER

Principal Investigators

• Angel Chamorro, MD, PhD · Comprehensive Stroke Center, Hospital Clinic Barcelona

• Arturo Renú, MD, PhD · Comprehensive Stroke Center, Hospital Clinic Barcelona

• Juan F Arenillas, MD · Hospital Universitario de Valladolid

• María del Mar Freijo, MD · Hospital Universitario de Cruces

• Patricia de la Riva, MD · Hospital Donostia

• M Dolores Fernándes, MD · Hospital Universitario de A Coruña

• Pedro Vega, MD · Hospital Universitario Central de Asturias

• Lluis Morales, MD · Hospital Universitario La Fe de Valencia

• Laura Dorado, MD · Hospital Germans Trias i Pujol de Badalona

• Mikel Terceño, MD · Hospital Universitario Dr. Josep Trueta de Girona

• Ana Morales, MD · Hospital Universitario Virgen de Arrixaca Murcia

• Maria Herrera, MD · Hospital of Navarra

• Raquel Delgado, MD · Hospital Universitario Son Espases Mallorca

• Nicolás López, MD · Hospital Universitario Dr. Balmis Alicante

• Pol Camps, MD · Hospital Universitario de la Santa Creu i Sant Pau Barcelona

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-11-18

Primary Completion

2025-08-26

Completion

2025-11-14

Countries

• Spain

Study Locations